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Threats of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may well lead to a rise in tramadol plasma concentrations and also a minimize from the levels of the active metabolite, M1.The effects of concom